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41.
V. A. Petrosyan L. V. Adaevskaya O. S. Chizhov A. Yu. Romanovich 《Russian Chemical Bulletin》1993,42(1):129-131
Direct electrochemical reduction of specially synthesized 2-[(diethoxyphosphorylacetoxy] benzaldehyde on a platinum electrode in an aprotic medium is accompanied by ester bond cleavage, and not formation of coumarin via the phosphonate-anion followed by intramolecular Horner cyclization. This could be realized, as a matter of principle, in the presence of an ionol anion (2,6-di-tert-butyl-4-methylphenoxide), electrochemically generatedin situ.Translated fromIzvestiya Akademii Nauk, Seriya Khimicheskaya, No. 1, pp. 144–146, January, 1993. 相似文献
42.
Bacteria communicate among themselves using certain chemical signaling molecules. These signaling molecules generally are
N-acyl homoserine lactones (AHLs) in Gram-negative bacteria and oligopeptides in Gram-positive bacteria. In addition, both
Gram-positive and Gram-negative bacteria produce a family of signaling molecules known as autoinducer-2 that they employ for
their communications. Bacteria coordinate their behavior by releasing and responding to the chemical signaling molecules present
in proportion to their population density. This phenomenon is known as quorum sensing. The role of bacteria in the pathogenesis
of several diseases, including gastrointestinal (GI) disorders, is well established. Moreover, rather recently bacterial quorum
sensing has been implicated in the onset of bacterial pathogenicity. Thus, we hypothesized that the signaling molecules involved
in bacterial communication may serve as potential biomarkers for the diagnosis and management of several bacteria-related
diseases. For that, we previously developed a method based on genetically engineered whole-cell sensing systems for the rapid,
sensitive, cost-effective and quantitative detection of AHLs in biological samples, such as saliva and stool, from both healthy
and diseased individuals with GI disorders. Although various analytical methods, based on physical-chemical techniques and
bacterial whole-cell biosensors, have been developed for the detection of AHLs in the supernatants of bacterial cultures,
only a few of them have been applied to AHL monitoring in real samples. In this paper, we report work performed in our laboratory
and review that from others that describes the detection of AHLs in biological, clinical samples, and report some of our recent
experimental results. 相似文献
43.
Hui Li 《Tetrahedron letters》2006,47(20):3485-3488
A general entry to C(1) aryl-substituted glycals from the corresponding sugar lactones is described. This approach features one-pot access to aryl glycals. A variety of aryllithium reagents can be used and the method is compatible with various 2-deoxysugar lactones. 相似文献
44.
Fürstner A Nagano T Müller C Seidel G Müller O 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(5):1452-1462
A comparative investigation shows that hydroxylated 10-membered lactones modeled around the fungal metabolites microcarpalide (1) and pinolidoxin (2) are endowed with selective actin-binding properties. Although less potent than the marine natural product latrunculin A, which represents the standard in the field, nonenolides of this type are significantly less toxic and accommodate substantial structural editing. Most notable is the fact that even an intramolecular transesterification with formation of a hydroxylated butanolide skeleton does not annihilate their microfilament disrupting capacity. This finding calls for a reinvestigation of the biological profile of other fungal metabolites that embody a similar motif. Microcarpalide (1) serving as the calibration point for this comparative study was prepared by total synthesis based on ring-closing metathesis (RCM) as the key step. The chosen route favorably compares to previous approaches to this target and provides further support for the notion that the (E,Z)-configuration of a medium-sized cycloalkene can be controlled by proper choice of the catalyst as previously outlined by our group. 9-epi-Microcarpalide 26 and furanone 27 as representative examples of the "natural productlike" compounds investigated herein have been characterized by crystal structure analysis. 相似文献
45.
In this study porous glass fiber membranes were modified by reaction with octadecyl-trichlorosilane to form C18 hydrophobic membranes. The contact angle and the CH2 vibration bands at 2855 and 2920 cm(-1) found by FTIR measurements verified the successful immobilization of C18 groups on the glass fiber membranes. The resulting C18 hydrophobic membranes were used to adsorb terpene lactones from crude Ginkgo biloba L. extracts. In batch adsorption processes, the modified C18 membranes exhibited a better adsorption performance than commercial C18 solid phase extraction adsorbents. Different desorption solvents were tested and ethyl acetate was found to preferentially desorb terpene lactones from the modified C18 membranes. In flow adsorption experiments at 1 mL/min, terpene lactone contents higher than 6 wt% (the standardized content) could be achieved in the elution step using ethyl acetate. 相似文献
46.
A range of room temperature 1,3-dipolar cycloaddition reactions of imines of 2-amino-γ-lactone and thiolactone, catalysed by a combination of AgOAc or Ag2O with NEt3 or DBU, are described. The spiro lactones/thiolactones are formed regio- and stereoselectively as single cycloadducts in good yield via the syn dipoles and an endo-transition states. 相似文献
47.
固相萃取-液相色谱-质谱/质谱法同时测定蜂蜜中的多类药物残留 总被引:4,自引:0,他引:4
建立了采用固相萃取-液相色谱-质谱/质谱(SPE-LC-MS/MS)对蜂蜜中磺胺类、硝基咪唑类、喹诺酮类、大环内酯类、林可酰胺类和吡喹酮共计6大类54种药物残留同时测定的方法。蜂蜜经磷酸盐缓冲溶液(pH 8)稀释,Oasis HLB固相萃取柱净化后,通过液相色谱-质谱联用技术进行检测(正离子方式,多反应监测模式)。采用同位素稀释内标法或外标法进行定量,线性关系良好,相关系数大于0.992。方法的定量限(LOQ,以信噪比(S/N)大于10计)分别为磺胺类和硝基咪唑类药物1.0 μg/kg,喹诺酮类和林可酰胺类药物2.0 μg/kg,大环内酯类药物3.0 μg/kg,吡喹酮0.3 μg/kg。总体回收率为32.6%~114%,相对标准偏差为1.3%~28.9%。该方法的定量限满足目前国内外药物的最大残留限量要求,可作为蜂蜜中相关药物残留量的筛选检测方法。 相似文献
48.
The essential oil of Helichrysum italicum (Roth) G. Don from Croatia has been fractionated into terpene and terpenoid fractions and analyzed using GC/MS. Fifty-two compounds were identified. The main hydrocarbons of the oil were α-pinene (10.2%), α-cedrene (9.6%) aromadendrene (4.4%), β-caryophyllene (4.2%), and limonene (3.8%), while the main oxygen-containing compounds were neryl acetate (11.5%), 2-methylcyclohexyl pentanoate (8.3%), 2-methylcyclohexyl octanoate (4.8%), and geranyl acetate (4.7%). The essential oil and its terpene and terpenoid fractions were evaluated for antibacterial and antifungal activities. The screening of antimicrobial activity was conducted by a disc diffusion test and the minimum inhibitory concentration was determined against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The essential oil and its terpenoid fraction exhibited higher antimicrobial activity with respect to the terpene fraction. The antimicrobial activities of the oil and its terpenoid fraction were more pronounced against Staphylococcus aureus and Candida albicans.__________Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 29–32, January–February, 2005. 相似文献
49.
Starting from the natural neo-clerodane diterpenoid teubotrin (1) several neo-clerodane derivatives (3-7,9-11) have been obtained. The naturally occurring diterpenoid teuscordinon (12) has also been synthesized from teubotrin (1), showing thereby how some of these transformations can be useful for the synthesis of other natural neo-clerodane diterpenes. The latter are of interest due to their activity as insect antifeedants and other important biological properties. 相似文献
50.
Mohamed Akssira Hakim Alilou Fadwa El Hanbali Alejandro F. Barrero 《Tetrahedron letters》2006,47(38):6719-6721
The aerial parts of Nauplius graveolens subsp. odorus (Schousb) Wikl. afforded a novel sesquiterpene lactone (1) named naupliolide together with the known 6,7,9,10-tetradehydroasteriscanolide 2 and asteriscunolides A-D 3a-d. The structure of compound 1 corresponds to a novel skeleton of 14,15-dimethyl-7,13-dioxotricyclic[6.4.0.09,11]dodeca-12,13-olide, and was established on the basis of spectroscopic methods including 2D-NMR. The coexistence of naupliolide 1 together with the structurally related sesquiterpene lactones asterisculolides A-D (3a-d) and 6,7,9,10-tetradehydroasteriscanolide 2, seems to indicate their biosynthetic relationship. 相似文献